Research · Articlepublished 8d
Human cortical organoids form working circuits in cortex-depleted mice
A peer-reviewed Nature study transplanted human stem-cell-derived cortical organoids into mice genetically engineered to lack most cortical and hippocampal glutamatergic neurons. The grafts occupied much of the vacant cortical space, formed organised activity and connected into the host nervous system, creating a new in-vivo model for human neurodevelopment and injury.
Nature — Developmental xenocortication using human-derived organoids in mice · Stanford Medicine — advanced model for studying brain development and disorders